Sorry but no.
You can peharps find a way by catching them with pubm and "return 1" if it's in a channel you want the ignore active (if exclusive-bind is set to 1) but it could become heavy resources consumming.
Whick kind of comands do you want to ignore and where/why ?
your using the wrong aproach you should have the public !commands restricted to the channels you want them to be used in i would use for example setudef for that.